League of Legends

General

Cast champion's 3rd ability on self (must be a support spell)

E + F1

All hotkeys for League of Legends

General
Use champion's 1st ability. For abilities that target a champion, you must follow this by either left-clicking the champion or pressing <keybs>F1</keybs> - <keybs>F5</keybs> to target a team member. Same for W, E, and R keys

Q

General
Use champion's 2nd ability

W

General
Use champion's 3rd ability

E

General
Use champion's 4th ability (Ultimate)

R

General
Add an ability point to the champion's 1st ability

Ctrl + Q

General
Add an ability point to the champion's 2nd ability

Ctrl + W

General
Add an ability point to the champion's 3rd ability

Ctrl + E

General
Add an ability point to the champion's ultimate ability

Ctrl + R

General
Cast champion's 1st ability on self (must be a support spell)

Alt + Q

General
Cast champion's 1st ability on self (must be a support spell)

Q + F1

General
Cast champion's 2nd ability on self (must be a support spell)

Alt + W

General
Cast champion's 2nd ability on self (must be a support spell)

W + F1

General
Cast champion's 3rd ability on self (must be a support spell)

Alt + E

General
Cast champion's 3rd ability on self (must be a support spell)

E + F1

General
Cast champion's ultimate ability on self (must be a support spell)

Alt + R

General
Cast champion's ultimate ability on self (must be a support spell)

R + F1

General
Smart cast champion's 1st ability

↑   Shift + Q

General
Smart cast champion's 2nd ability

↑   Shift + W

General
Smart cast champion's 3rd ability

↑   Shift + E

General
Smart cast champion's 4th ability

↑   Shift + R

General
Attack Move (Champion moves to point, stopping to attack any enemies along the way)

A

General
Attack Move (Champion moves to point, stopping to attack any enemies along the way)

X

General
Attack Move (Champion moves to point, stopping to attack any enemies along the way)

↑   Shift + Mouse right click

General
Command Pet (E.g. TibbersSquare Tibbers)

Alt + Mouse right click

General
Stop Command (Champion stops their current course of action)

S

General
Hold Command (Hold works like Stop, but is toggled while held down)

H

General
Cast 1st Summoner spell

D

General
Cast 2nd Summoner spell

F

General
...to <keybs>3</keybs> and <keybs>5</keybs> to <keybs>7</keybs>:  Use consumable item in corresponding inventory slot

1

General
Use trinket

4

General
Recall

B

General
Close current window, such as the shop

Esc

General
Open champion statistics page

C

General
Toggle alert ping cursor

G

General
Toggle camera lock on champion

Y

General
Center camera on champion (holding Space will hold the camera on the champion until released)

Space

General
Open match stats page/leaderboard

O

General
Open match stats page/leaderboard (unlike <keybs>O</keybs>, the screen will disappear when the <keybs>Tab</keybs> button is released)

⭾ Tab

General
Toggle retreat ping cursor. Clicking with this hotkey on an allied champion (or their icon in the upper left area of the screen) will show an alert telling that specific champion to fall back

V

General
Cycle through minion health bar views

Ctrl + L

General
Turn off champion health bars

↑   Shift + L

General
Turn off summoner names above champion health bars

↑   Shift + K

General
Open item shop

P

General
Scroll camera in the corresponding direction

← ↑ → ↓

General
Ping location/Open Radial Menu

Alt + Mouse left click

General
Retreat Ping location/Open Radial Menu

Ctrl + Mouse left click

General
Move camera to corresponding ally champion (camera must be unlocked)

F2

General
Move camera to corresponding ally champion (camera must be unlocked)

F3

General
Move camera to corresponding ally champion (camera must be unlocked)

F4

General
Move camera to corresponding ally champion (camera must be unlocked)

F5

General
Take a screenshot

F12

General
Create chat cursor

⤶ Enter

General
Open chat with "/all" already written

↑   Shift + ⤶ Enter

General
Toggle the numeric frames-per-second and latency display

Ctrl + F

General
Open chat history

Z

General
Hold down to select or target only champions when using champion abilities or summoner spells

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Similar combinations for other applications