Fill With Secondary Color (hold Shift to preserve transparency)

`Shift` + `Backspace`

All hotkeys for Pixelmator (MacOS)

Palettes/Panels Show / Hide Tools palette/panel	`Cmd` + `1`
Palettes/Panels Show / Hide Layers palette/panel	`Cmd` + `2`
Palettes/Panels Show / Hide Effects browser	`Cmd` + `3`
Palettes/Panels Show / Hide Brushes palette/panel	`Cmd` + `4`
Palettes/Panels Show / Hide Gradients palette/panel	`Cmd` + `5`
Palettes/Panels Show / Hide Photo browser	`Cmd` + `6`
Palettes/Panels Show / Hide Colors palette/panel	`Shift` + `Cmd` + `C`
Palettes/Panels Show / Hide Fonts palette/panel	`Cmd` + `T`
Palettes/Panels Reset palettes/panels to default location	`Shift` + `Cmd` + `R`
Selection Tools Move	`V`
Selection Tools Zoom	`Z`
Selection Tools Eyedropper	`I`
Selection Tools Hand	`H`
Selection Tools Type	`T`
Selection Tools Crop	`C`
Selection Tools Slice	`K`
Selection Tools Elliptical Marquee	`Y`
Selection Tools Rectangular Marquee	`M`
Selection Tools Lasso	`L`
Selection Tools Magic Wand	`W`
Selection Tools Brush	`B`
Selection Tools Pixel	`P`
Selection Tools Eraser	`E`
Selection Tools Paint Bucket	`N`
Selection Tools Gradient	`G`
Selection Tools Clone Stamp	`S`
Selection Tools Sharpen	`O`
Selection Tools Red Eye	`R`
File Create New File	`Cmd` + `N`
File Open Existing File	`Cmd` + `O`
File Close Window	`Cmd` + `W`
Save Save file	`Cmd` + `S`
Save Export For Web	`Shift` + `Cmd` + `E`
View Zoom In	`Cmd` + `+`
View Zoom Out	`Cmd` + `-`
View Zoom In / Out	`Option` + `Scroll Mouse`
View Horizontal Scrolling	`Shift` + `Scroll Mouse`
View Fit Image In Window	`Cmd` + `0`
View Magnify 100%	`Option` + `Cmd` + `0`
View Show / Hide Rulers	`Cmd` + `R`
View Show / Hide Guides	`Option` + `Cmd` + `;`
View Show / Hide Grid	`Option` + `Cmd` + `'`
View Snap Guide To Ruler	`Shift` + `Drag Guide`
View Full-screen On / Off	`Cmd` + `Ctrl` + `F`
View Quick Mask Mode On / Off	`Q`
Edit Undo Last Action	`Cmd` + `Z`
Edit Redo Last Action	`Shift` + `Cmd` + `Z`
Edit Fill With Color	`Option` + `Cmd` + `F`
Edit Fill With Primary Color (hold Shift to preserve transparency)	`Cmd` + `Backspace`
Edit Fill With Secondary Color (hold Shift to preserve transparency)	`Shift` + `Backspace`
Edit Stroke	`Shift` + `Cmd` + `O`
Edit Invert Color	`Cmd` + `I`
Edit Edit Levels	`Cmd` + `L`
Edit Edit Curves	`Cmd` + `K`
Edit Edit Color Balance	`Cmd` + `B`
Edit Edit Hue And Saturation	`Cmd` + `U`
Edit De-saturate	`Option` + `Cmd` + `U`
Edit Edit Canvas Size	`Option` + `Cmd` + `C`
Edit Edit Image Size	`Option` + `Cmd` + `I`
Edit Color Management	`Shift` + `Cmd` + `K`
Edit Soft Proof	`Shift` + `Option` + `P`
Edit Last Filter	`Shift` + `Cmd` + `F`
Working With Selections Add To Selection	`Hold Shift as you drag selection`
Working With Selections Subtract From Selection	`Hold Shift` + `Option as you drag selection`
Working With Selections Constrain To A Circle Or Square	`Shift` + `Drag Selection`
Working With Selections Select All	`Cmd` + `A`
Working With Selections De-select	`Cmd` + `D`
Working With Selections Load layer transparency as selection	`Option` + `Cmd` + `L`
Working With Selections Refine Selection	`Option` + `Cmd` + `R`
Working With Selections Copy	`Cmd` + `C`
Working With Selections Cut	`Cmd` + `X`
Working With Selections Paste	`Cmd` + `V`
Working With Selections Duplicate	`Shift` + `Cmd` + `D`
Working With Layers Transform Layer	`Cmd` + `F`
Working With Layers Lock Layer	`/`
Working With Layers Cycle Layer Blending Modes	`Shift` + `+` or `-`
Working With Layers Select All Layers	`Option` + `Cmd` + `A`
Working With Layers Hide Other Layers	`Option` + `click layer visibility check-box`
Working With Layers Place New Image In The Canvas Center	`Shift` + `Drag File From Finder`
Working With Layers Create / Release Clipping Mask	`Option` + `Cmd` + `G`
Working With Layers Link Layers	`Shift` + `Cmd` + `L`
Working With Layers Merge Selected Layers	`Cmd` + `E`
Working With Layers Group Layers	`Cmd` + `G`
Working With Layers Ungroup Layers	`Shift` + `Cmd` + `G`
Working With Layers Create New Layer	`Shift` + `Cmd` + `N`
Working With Layers Rename Layer	`Double Click Layer Name`
Working With Layers Duplicate Layer	`Option` + `Drag Layer`
Working With Layers Select Top Layer	`Option` + `.`
Working With Layers Select Next Layer	`Option` + `]`
Working With Layers Select Previous Layer	`Option` + `[`
Working With Layers Select Bottom Layer	`Option` + `,`
Working With Layers Bring Layer To Front	`Option` + `Cmd` + `]`
Working With Layers Send Layer To Back	`Option` + `Cmd` + `[`
Working With Layers Bring Layer Forward	`Cmd` + `]`
Working With Layers Send Layer Backward	`Cmd` + `[`
Move Move Layer / Selection by 1px	`Cmd` + `Arrow Key`
Move Move Layer / Selection by 10px	`Shift` + `Cmd` + `Arrow Key`
Move Move Selection Border by 1px	`Arrow Key`
Move Move Selection Border by 10px	`Shift` + `Arrow Key`
Paint Open Brush Settings	`Double Click Brush`
Paint Paint Straight Lines	`Shift` + `Mouse Click`
Paint Paint Vertical / Horizontal Lines	`Shift` + `Drag Mouse`
Paint Switch Between Primary And Secondary Colors	`X`
Paint Navigate Through Brushes/Navigate Through Gradients	`.` or `,`
Paint Increase / Decrease Brush Size/Cycle Through Gradients	`[` or `]`
Paint Change Brush Hardness	`Shift` + `[` or `Shift` + `]`
Paint Constrain Gradient To 45° Angle	`Shift` + `Drag Gradient`
Paint Delete Brush From Brushes Palette/Panel	`Option` + `Click Brush`
Paint Sample Background Color	`Option` + `Mouse Click`
Print Print	`Cmd` + `P`
Print Page Setup	`Shift` + `Cmd` + `P`
General Show Preferences	`Cmd` + `,`
General Check Spelling	`Cmd` + `;`
General Get File Info	`Shift` + `Option` + `Cmd` + `I`
General Close Window	`Cmd` + `W`
General Close All Windows	`Option` + `Cmd` + `W`
General Cycle Through Windows	`Cmd` + `'`
General Minimize Window	`Cmd` + `M`
General Minimize All Windows	`Option` + `Cmd` + `M`
General Hide Pixelmator	`Cmd` + `H`
General Hide Others	`Option` + `Cmd` + `H`
General Active/deactive Vectormator Mode	`Shift` + `Cmd` + `V`
General Quit Pixelmator	`Cmd` + `Q`